Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them

US5453422A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Uwe Petersen · Leverkusen, DE
• Thomas Schenke · Odenthal, DE
• Klaus Grohe · Odenthal, DE
• Michael Schriewer · Odenthal, DE
• Ingo Haller · Wuppertal, DE
• Karl G. Metzger · Wuppertal, DE
• Rainer Endermann · Wuppertal, DE
• Hans-Joachim Zeiler · Velbert, DE

Key dates

• Filing date: Nov 12, 1993
• Grant date: Sep 26, 1995
• Expiry date: Nov 12, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical, PA1 R.sup.2 stands for hydrogen, alkyl having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl, PA1 R.sup.3 stands for hydrogen or amino, PA1 R.sup.4 stands for a radical of the formula ##STR2## A stands for N or C--R.sup.5, wherein PA1 R.sup.5 stands for hydrogen, halogen methyl, cyano or nitro or else together with R.sup.1 can form a bridge of the structure ##STR3## or a pharmaceutically utilizable hydrate, acid addition salt, alkali metal salt, alkaline earth metal salt, silver salt or guanidinium salt of the carboxylic acid when R.sup.2 is hydrogen.