N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidone
US5453434A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 24, 1994 |
| Grant date | Sep 26, 1995 |
| Priority date | — |
| Expiry date | Jun 24, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to new carbonyl 3R, 4R-ethyl-[(1-methyl-1H-imidzaol-5-yl)methyl]-2-pyrrolidinone derivatives carrying a carboxyester-type lipophilic moiety on the pyrrolidinone nitrogenand are valuable antiglaucoma agents and targeted for use in the treatment of so-called dry eye. More particularly, the present invention concerns new N-substituted carbonyl-3R, 4R-ethyl-[(1-methyl-1H-imidazol-5-7)methyl]-2-pyrrolidinone derivatives of the formula (I): ##STR1## wherein R is selected from the group consisting of ##STR2## wherein R.sup.1 is a halo radical, e.g. a chloro radical, or a lower alkyl radical, e.g. a methyl or ethyl radical, with the proviso that when m is 1, R.sup.1 is not methyl or t-butyl, m is an integer of 1 or 2, n is 0 or an integer of 1 or 2 and X is O or S, and pharmaceutically-acceptable acid addition salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.