Preparation of stable injectable .beta.-carotene solubilizates

US5453447A · kind A · utility

Assignee

• BASF SE

Inventors

• Lutz End · Mannheim, DE
• Dieter Horn · Heidelberg, DE
• Erik Lueddecke · Mutterstadt, DE
• Jachim U. Schneider · Bad Dürkheim, DE
• Peter P. Hoppe · Monsheim, DE
• Friedrich-Wilhelm Rensmann · Bad Dürkheim, DE

Key dates

• Filing date: Oct 1, 1991
• Grant date: Sep 26, 1995
• Expiry date: Oct 1, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the continusous preparation of Beta-carotene together with an emulsifier by briefly heating Beta-carotene together with an emulsifier to give a homogeneous solution, rapidly cooling the latter to below 100.degree. C. by adding water, and subsequently adjusting to the required final concentration of Beta-carotene, comprises pumping a suspension, which has been preheated from 20.degree. to 80.degree. C., of 1 to 40% by weight of Beta-carotene in an emulsifier through a heating coil located in a heat transfer oil, where the solubilization mixture is at from 120.degree. to 180.degree. C. and the residence time is from 10 to 300 seconds, and subjecting the homogenous solution to turbulent mixing in a mixing chamber with an amount of water at from 10.degree. to 80.degree. C. to result in a solubilizate which contains from 0.5 to 6% by weight of Beta-carotene and is, if necessary, diluted to the required final concentration.