Patent · US Expired

Neuromuscular blocking agents

US5453510A · kind A · utility

27Cited by
5References
24Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 10, 1992
Grant dateSep 26, 1995
Priority date—
Expiry dateJul 10, 2012

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D217/20
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

1R-cis,1'R-cis isomer of a 2',2'-(3,11-dioxo-4,10-dioxatridecylene)-bis(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-veratrylisoquinolium) said, substantially free from other geometrical and optical isomers thereof. The 1R-cis,1'R-cis isomer has been found to have an advantageous combination of pharmacological properties, notably greater neuromuscular blocking potency, weaker histamine-releasing potency, and at equivalent levels of neuromuscular blockade, fewer potential adverse effects on the autonomic nervous system (sympathetic and parasympathetic blockage), in comparison with the known mixture of geometrical and optical isomers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.