Phosphorus-containing isoprenoid derivatives
US5453524A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 22, 1994 |
| Grant date | Sep 26, 1995 |
| Priority date | — |
| Expiry date | Feb 22, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a phosphorus-containing isoprenoid derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is useful as a preventive and therapeutic agent for diseases for which a squalene synthetase inhibiting action is efficacious: ##STR1## wherein R.sup.1 and R.sup.2 each represent a hydrogen atom, a lower alkyl, cycloalkyl, alkenyl or alkynyl group, an aryl group which may be substituted, an arylalkyl group in which the aryl group may be substituted, or a heteroaryl or heteroarylalkyl group: R.sup.3 and R.sup.4 each represent a hydrogen atom, a lower alkyl group or an alkali metal; Y represents a group represented by the formula: ##STR2## (wherein R.sup.5 and R.sup.6 each represent a hydrogen atom, a lower alkyl group or an alkali metal or a group represented by the formula: --CO.sub.2 R.sup.7 (wherein R.sup.7 represents a hydrogen atom, a lower alkyl group or an alkali metal); Z represents a group represented by the Formula: --(CH.sub.2).sub.m -- (wherein m is an integer of 0 to 3), a group represented by the formula: --(CH.sub.2).sub.p --CH.dbd.CH--(CH.sub.2).sub.q -- (wherein p is 0 or 1 and q is 1 or 2…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.