Terfenadine oral powder
US5455049A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 4, 1995 |
| Grant date | Oct 3, 1995 |
| Priority date | — |
| Expiry date | Jan 4, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/445
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention contemplates a dry, powdered terfenadine composition. That composition comprises PA1 (a) a mixture of: PA2 (i) about 1 to about 20 parts by weight micronized terfenadine and PA2 (ii) about 0.2 to about 10 parts by weight a polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymer having an HLB number of 24 that is a wetting agent for said terfenadine; PA1 that are dry-blendedly dispersed into: PA1 (b) about 20 to about 40 parts by weight spray-dried sorbitol particles that are loosely packed, randomly oriented filamentary crystals having pores that entrap said terfenadine particles and wetting agent upon said dry-blended dispersal, said components being further dry blended with PA1 (c) about 2 to about 10 parts by weight dry polyvinylpyrrolidone; PA1 (d) about 1 to about 5 parts by weight of a dry mixture of microcrystalline cellulose and sodium carboxymethylcellulose; and PA1 (e) a dry flavorant in an amount sufficient to provide a desired taste to said powder; PA1 said composition being a free-flowing powder that is substantially free from the taste of terfenadine when placed on the human tongue in dry form or when dispersed in water and tast…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.