Carcinoma-marking monoclonal antibodies elicited with synthetic Asialo-GM1 antigen
US5455332A · kind A · utility
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5Claims
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Key dates
| Filing date | May 12, 1989 |
| Grant date | Oct 3, 1995 |
| Priority date | — |
| Expiry date | May 12, 2009 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/28
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Monoclonal antibodies produced after immunization with a synthetic antigen bearing the structure Gal (beta 1-3) GalNac beta-glycosidically linked to a carrier moiety are useful as carcinoma markers. Radioimmunoimaging agents are described in which such antibodies are tagged with radiometals or radiohalogens. Radiolabeled monoclonal antibody 155H.7, elicited by this antigen, rapidly localizes and persists in tumor tissues, demonstrating its utility as a tumor imaging agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.