Methods of promoting bone growth in mammals comprising administration of modified parathyroid hormone

US5457092A · kind A · utility

Assignee

• Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE

Inventors

• Klaus Schluter · Braunschweig, DE
• Hubert Mayer · Braunschweig, DE
• Edgar Wingender · Wolfenbüttel, DE

Key dates

• Filing date: Sep 13, 1993
• Grant date: Oct 10, 1995
• Expiry date: Sep 13, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

pPTH, bPTH or hPTH is modified by deletions from the natural C- and/or N-terminus. The modified compounds are useful active ingredients in therapeutic compositions. The therapeutic compositions do not stimulate renal adenylate cyclase but, rather, effect chondrocyte proliferation, that is to say, they exhibit a mitogenic and bone-specific effect.