Methods for producing linear thiopeptides using an amino acid ortho amino thioanilide compound
US5457180A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 13, 1994 |
| Grant date | Oct 10, 1995 |
| Priority date | — |
| Expiry date | Jun 13, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for producing linear thiopeptides using an amino acid ortho amino thioanilide compound of formula (III) ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen or C.sub.1 -C.sub.4 branched or unbranched alkyl; PA1 R.sub.2 is selected from the group consisting of hydrogen, halo, amino, hydroxy, C.sub.1 -C.sub.4 branched or unbranched alkoxy, guanido, amido, acyl, carboxy, cyano, mercapto, nitro, azido, and C.sub.1 -C.sub.4 branched or unbranched alkyl optionally substituted by halo, amino, hydroxy, C.sub.1 -C.sub.4 branched or unbranched alkoxy, guanido, amido, acyl, carboxy, cyano, mercapto, nitro, azido; PA1 R.sub.3 is a decarboxylated amino acid residue or a decarboxylated amino acid chain comprising at least two amino acid residue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.