Hydroxy protecting group removal in penems
US5457193A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1995 |
| Grant date | Oct 10, 1995 |
| Priority date | — |
| Expiry date | Mar 6, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates the removal of t-butyldimethylsilyl protecting groups in the preparation of penems which are useful antibiotics. The invention provides a process for preparing a compound of the formula I: ##STR1## wherein R is a free or protected hydroxy or amino group or an alkoxy, acyloxy or an optionally substituted carbamoyloxy group, and R.sub.1 is selected from: PA1 a) hydrogen; PA1 b) a C.sub.2 -C.sub.4 alkenyl group; PA1 c) a p-NO.sub.2 benzyl group; PA1 d) a linear or branched alkanoyloxy C.sub.1 -C.sub.2 alkyl group; and PA1 e) (2-oxo-1,3-dioxolen-4-yl)methyl optionally substituted by C.sub.1 -C.sub.4 alkyl at the 5-position or a pharmaceutically acceptable salt thereof, which process comprises reacting a compound of the formula II: ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.