Resolution of 5-methyltetrahydrofolic acid

US5457202A · kind A · utility

Assignee

• Knoll, Inc. · DE

Inventors

• Klaus Scheib · Schauernheim, DE
• Peter Klein · Itzehoe, DE
• Robert Carter · Thorold, CA

Key dates

• Filing date: May 6, 1994
• Grant date: Oct 10, 1995
• Expiry date: May 6, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing (6S)-5-methyltetrahydrofolic acid by resolution of racemic (6R,S)-5-methyltetrahydrofolic acid using a base, wherein the base is N-ethyl-2-aminomethylpyrrolidine or its optical isomers.