Benzimidazole anthelmintic agents
US5459155A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1994 |
| Grant date | Oct 17, 1995 |
| Priority date | — |
| Expiry date | Jan 14, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention is directed to anthelmintic benzimidazole compounds of formula (IA) or (IB) ##STR1## or non-toxic salts thereof, wherein R, which in the compounds (IA) is in the 5- or 6- position, is H, benzoyl, styryl, phenyloxy, phenylthio, phenylsulfinyl, phenylsulfonyl, phenylsulfonyloxy, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulfinyl, C.sub.1 -C.sub.6 alkylsulfonyl or (C.sub.3 -C.sub.7 cycloalkyl) carbonyl, said phenyl groups, and the phenyl portion of said benzoyl group, optionally having 1 to 3 substituents each independently selected from halo, C.sub.1 -C.sub.4 alkyl, halo-(C.sub.1 -C.sub.4 alkyl), C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.2 -C.sub.4 alkanoyl, nitro, isothiocyanato, and cyano; and either (a) R.sup.1 is a 1- (C.sub.2 -C.sub.6 alkanoyloxy) (C.sub.1 -C.sub.4 alkyl) group and R.sup.2 is H, C.sub.1 -C.sub.4 alkyl or a 1-(C.sub.1 -C.sub.4 alkyl) group, or (b) R.sup.1 is H and R.sup.2 is a 1- (C.sub.2 -C.sub.6 alkanoyloxy) (C.sub.1 -C.sub.4 alkyl) group; and R.sup.3 is a C.sub.1 -C.sub.4 alkyl group; pharmaceutical compositio…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.