Process for the preparation of 2-halogeno-5-cyano pyridines

US5459273A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Helmut Kraus · Cologne, DE
• Hans-Joachim Traenckner · Leverkusen, DE

Key dates

• Filing date: Mar 8, 1994
• Grant date: Oct 17, 1995
• Expiry date: Mar 8, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/85
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The title compounds of the formula ##STR1## can be prepared by reacting methylene-glutaconic acid dinitriles of the formula EQU R.sup.1 --CH.dbd.C(CN)--CH'CH--CN (II) with hydrogen halide of the formula EQU HX (III) In these formulae, PA1 X denotes fluorine, chlorine, bromine or iodine and PA1 R.sup.1 denotes --OR.sup.2 or --N(R.sup.2, R.sup.3), PA2 in which R.sup.2 and R.sup.3, independently of one another, represent straight-chain or branched C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.8 -alkenyl, C.sub.2 -C.sub.8 -alkoxyalkyl, C.sub.4 -C.sub.8 -alkoxyalkenyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.6 -C.sub.12 -aryl, C.sub.7 -C.sub.10 -aralkyl or a 5- to 8-membered saturated or unsaturated heterocyclic ring containing 1 or 2 heteroatoms from the group comprising N, O and S, where R.sup.2 and R.sup.3, with the N atom on which they are substituents, may also form a 5- to 8-membered ring which may contain a further heteroatom from the group comprising N, O and S.