Diphenylmethane derivatives, process for their production and their use for the displacement of iodothyronines from proteins which bind them

US5460975A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Helmut Freitag · Indianapolis, US
• Wolfgang-Reinhold Knappe · Ludwigshafen, DE
• Heino Eikmeier · Lorsch, DE
• Wolfgang Weckerle · Grünstadt, DE

Key dates

• Filing date: Jul 7, 1993
• Grant date: Oct 24, 1995
• Expiry date: Jul 7, 2013

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/78
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention concerns compounds having the general formula I ##STR1## in which R.sup.1 denotes hydrogen or hydroxy, PA1 R.sup.2 denotes hydrogen or hydroxy, PA1 R.sup.3 denotes hydrogen or alkoxy, PA1 R.sup.4 denotes hydrogen, CO.sub.2 H, SO.sub.3 H, PO.sub.3 H.sub.2 or a salt of the corresponding acid, PA1 R.sup.5 denotes CO.sub.2 H, SO.sub.3 H, PO.sub.3 H.sub.2 or a salt of the corresponding acid and PA1 R.sup.6 denotes alkoxy, their use for displacing iodothyronines from proteins binding them, as well as a method and reagent for the determination of iodothyronine in which such compounds are used.