Osteogenic growth polypeptides identified from regenerating bone marrow

US5461034A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Gideon A. Rodan · Via Enrico Fermi, US
• John W. Jacobs · Des Moines, US
• Mohinder K. Sardana · Lansdale, US
• Dan Gazit · Modiin-Maccabim-Reut, IL
• Michael Chorev · Sharon, US
• Andras Muhlrad · Jerusalem, IL
• Arye Shteyer · Jerusalem, IL
• Nura Mansur
• Zvi Greenberg · Ramat HaSharon, IL
• Shimon Slavin · Jerusalem, IL
• Olga Gurevitch · Jerusalem, IL
• Itai Bab · Mazkeret Batya, IL

Key dates

• Filing date: Jun 18, 1993
• Grant date: Oct 24, 1995
• Expiry date: Jun 18, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/841
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction. OGP, identified from regenerating bone marrow, has an amino acid sequence of EQU Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly.