Fused benzeneoxyacetic acid derivatives
US5461045A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 1992 |
| Grant date | Oct 24, 1995 |
| Priority date | — |
| Expiry date | Jul 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A fused benzeneoxyacetic acid derivative of the formula: ##STR1## wherein ##STR2## is (i) ##STR3## (ii) ##STR4## (iii) ##STR5## or (iv) ##STR6## A is (i) ##STR7## or (ii) ##STR8## R.sup.1 is hydrogen or C.sub.1-4 alkyl; R.sup.2 is hydrogen, C.sub.1-6 alkyl or phenyl; PA1 R.sup.3 is PA2 (i) C.sub.1-15 alkyl, PA2 (ii) C.sub.1-8 alkyl substituted by one or two of benzene, C.sub.4-7 cycloalkane or 4-7 ring-membered monocyclic ring which contains one nitrogen atom or PA2 (iii) C.sub.10-15 condensed tricyclic ring; PA1 e is 3-5; PA1 f is 1-3; PA1 p is 0-4; PA1 q is 0-2; PA1 s is 0-3 With the proviso that, ring(s) in R.sup.3 may be substituted by one to three of C.sub.1-4 alkyl, .sub.1-4 alkoxy, halogen atom, nitro or trihalomethyl. And, when D--B is the formula (iii) or (iv), --(CH2)p- or .dbd.CH--(CH2)s- is attached at the position of a or b on the ring. and non-toxic salts thereof possess an antagonistic activity on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.