Amide tetrazole ACAT inhibitors
US5461049A · kind A · utility
9Cited by
4References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 27, 1994 |
| Grant date | Oct 24, 1995 |
| Priority date | — |
| Expiry date | May 27, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D257/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amide tetrazoles of the formula ##STR1## wherein aryl includes phenyl and naphthyl, unsubstituted or substituted, X is .dbd.O, .dbd.N--R.sub.5, or --NR.sub.3 R.sub.4, where R.sub.2, R.sub.4, and R.sub.5 include alkyl and alkoxy and R.sub.3 includes alkyl, are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia or atherosclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.