4-amino-1-piperidylbenzoylguanidines

US5461066A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Manfred Baumgarth
• Dieter Dorsch · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Ingeborg Lues · Darmstadt, DE

Key dates

• Filing date: Feb 9, 1995
• Grant date: Oct 24, 1995
• Expiry date: Feb 9, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-amino-1-piperidylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the given meanings, and also the physiologically compatible salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.