Patent · US Expired

Phosphorylated derivatives of cardiodilatin/ANF peptides

US5461142A · kind A · utility

6Cited by

1References

5Claims

0Family size

Assignees

Pharma Bissendorf Peptide GmbH · DE
Wolf-Georg Forssmann · DE

Inventors

Wolf-Georg Forssmann · Hannover, DE
Michael Gagelmann · Schriesheim, DE
Dieter Hock · Neckarbischofsheim, DE

Key dates

Filing date	Jul 22, 1993
Grant date	Oct 24, 1995
Priority date	—
Expiry date	Jul 22, 2013

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Described are derivatives of the precursor peptide of the cardiodilatin/atrial sodiuretic factor (CDD-ANF) or fragments thereof which comprise at least the amino acid sequence of alpha-hANaP. The derivatives according to the present invention are compounds of the formula (I) ##STR1## X is a phosphate or thiophosphate group. R is NH.sub.2 or a peptide fragment from the amino acid sequence of gamma-hANaP. Radio-labelled derivatives are also possible. A method for the qualitative and/or quantitative determination of peptides containing the sequence of alpha-hANaP and a use of the compounds having the formula (I) as medicaments for various vaso- and renal related disorders are further described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.