Covalent attachment of macromolecules to polysulfones or polyethersulfones modified to contain functionalizable chain ends
US5462867A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 2, 1994 |
| Grant date | Oct 31, 1995 |
| Priority date | — |
| Expiry date | Feb 2, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/816
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
A hydrophobic polymer such as polysulfone or polyethersulfone is modified to contain an increased number of functionalizable chain ends such as by treating with an alkali hydroxide to provide hydroxyl groups. A linker is covalently bonded to a chain end of the polymer and a macromolecule is covalently bonded to the linker. A ligand may be covalently bonded to the macromolecule. The macromolecule can be a natural polymer, a synthetic polymer or a biologically active species. The hydrophobic polymer is preferably in the form of a microporous membrane. By the use of a four-component dope composition, substantially isotropic microporous structures in the form of flat sheets or hollow fibers are produced. An improved spinnerette assembly is provided for the production of hollow fibers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.