Substituted phenyl phenol leukotriene antagonists
US5462954A · kind A · utility
22Cited by
30References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1994 |
| Grant date | Oct 31, 1995 |
| Priority date | — |
| Expiry date | Nov 1, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/86
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and synthesis are disclosed. Also, pharmaceutical formulations are disclosed for use in applications treating diseases or conditions characterized by excessive release of leukotriene B.sub.4, one of the metabolites of arachidonic acid. The primary LTB.sub.4 antagonistic structures are represented as: ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.