Process for preparing benzazepine intermediates for the synthesis of D1 antagonists

US5463051A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Donald Hou · Verona, US
• Richard W. Draper · North Caldwell, US
• Gary M. Lee · West Hollywood, US
• Janet L. Mas · Scotch Plains, US
• Ingrid Mergelsberg · Mahwah, US

Key dates

• Filing date: Sep 27, 1993
• Grant date: Oct 31, 1995
• Expiry date: Sep 27, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are a process and intermediates of the formulae ##STR1## wherein X.sup.- is halide, BF.sub.4.sup.-, R.sup.3 SO.sub.3.sup.-, wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl, CF.sub.3, C.sub.1 -C.sub.6 alkylphenyl or phenyl, and Q is a group of the formula ##STR2## wherein R is C.sub.1 -C.sub.6 alkyl; useful for preparing benzazepine intermediates of the formula ##STR3## These benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.