Process for production of glycide derivative
US5463061A · kind A · utility
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15Claims
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Key dates
| Filing date | Jan 13, 1994 |
| Grant date | Oct 31, 1995 |
| Priority date | — |
| Expiry date | Jan 13, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A glycide derivative represented by the following general formula (I) is produced by reacting a hydroxyaryl or heteroaryl represented by A-OH with glycidyl tosylate in the presence of a cesium base as a base. Thereby, an aryl glycidyl ether derivative, which is an important intermediate for drug production, can be produced easily and reliably. Particularly when optically active glycidyl tosylate is used, said compound can be obtained at a high optical purity. ##STR1## wherein A represents an aryl group or a heteroaryl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.