Process for the diastereoselective reductive pinacol coupling of homochiral .alpha.-aminoaldehydes

US5463124A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Detlef Jacobi · Esslingen am Neckar, DE
• Heiner Jendralla · Frankfurt, DE
• Bernhard Kammermeier · Frankfurt, DE

Key dates

• Filing date: Jun 22, 1994
• Grant date: Oct 31, 1995
• Expiry date: Jun 22, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the diastereoselective reductive pinacol coupling of homochiral .alpha.-aminoaldehydes A process for the preparation of optically pure symmetrical compounds of the formula I ##STR1## is described in which R.sup.1, R.sup.2 and R.sup.3 are explained in the description, with simultaneous control of the four centers of chirality marked by *.