Glycoprotein ligand for P-selectin and methods of use thereof
US5464778A · kind A · utility
51Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 21, 1994 |
| Grant date | Nov 7, 1995 |
| Priority date | — |
| Expiry date | Jul 21, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [.sup.3 H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.
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