Amino naphthyridine compounds as anti-rhoumatic agents
US5464781A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 3, 1994 |
| Grant date | Nov 7, 1995 |
| Priority date | — |
| Expiry date | Jun 3, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds of formula I and pharmaceutically acceptable salts thereof ##STR1## in which R.sub.1 represents hydrogen, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonyalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy alkoxycarbonyl or alkanoylamino; R.sub.2 represents hydrogen, halo, alkoxy, hydroxy, alkanoyloxy, or phenoxy; R.sub.3 represents hydrogen or alkyl; R.sub.4 represents hydrogen, halo, alkoxycarbonyl, a benzyloxycarbonyl, alkanoyl, benzoyl, carbamoyl, alkyl, carboxy, hydroxyalkyl or alkylthio; R.sub.5 represents hydrogen or alkyl; R.sub.6 represents hydrogen, alkyl [optionally substituted by one or more of the following: hydroxy, halo or an amino group of formula --NR.sub.12 R.sub.13 ], a C.sub.3-12 alicyclic hydrocarbon group, phenyl, (cycloalkyl)alkyl or benzyl; R.sub.7 represents hydrogen, halo, trifluoromethyl, trifluoromethoxy, alkyl, carboxy, or alkoxy; R.sub.8 represents hydrogen, halo, trifluoromethyl, trifluoromethoxy, alkyl or alkoxy; and R.sub.9 represents hydrogen or alkyl; which are antirheumatic agents. Compositions containing these compounds and processes to make them are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.