Compositions of iodophenoxy alkylene ethers and cellulose derivatives for visualization of the gastrointestinal tract

US5466435A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Edward J. Baker · Rothbury, GB
• Edward R. Bacon · East Greenbush, US
• Carl R. Illig · Phoenixville, US
• Thomas J. Caulfield · Lawrenceville, US
• Brent Douty · Coatesville, US
• Kurt A. Josef · Wayne, US
• John L. Toner · Libertyville, US
• Robert W. Lee · Gilbertsville, US

Key dates

• Filing date: Apr 4, 1994
• Grant date: Nov 14, 1995
• Expiry date: Apr 4, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C43/225
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are contrast agents of the formula ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; PA2 R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy; EQU (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; PA2 R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H or lower-alkyl, optionally substituted with halo; PA2 x is 1-4; PA2 n is 1-4; PA2 m is 1-15; PA2 p is 1-20; and PA2 Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl; PA1 in an aqueous, pharmaceutically acceptable carrier comprising a cellulose derivative.