Superior thrombomodulin analogs for pharmaceutical use
US5466668A · kind A · utility
27Cited by
0References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1993 |
| Grant date | Nov 14, 1995 |
| Priority date | — |
| Expiry date | Nov 22, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the use of analogs of thrombomodulin ("TM") that have the ability to enhance the thrombin-mediated activation of protein C but which have a significantly reduced ability to inhibit the direct procoagulant activities of thrombin, such as, for example, thrombin-mediated conversion of fibrinogen to fibrin. These analogs are useful in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed. Included are methods for increasing the circulating half life of the proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.