Process for the manufacture of mannitol
US5466795A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 12, 1993 |
| Grant date | Nov 14, 1995 |
| Priority date | — |
| Expiry date | Jul 12, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/24
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the manufacture of mannitol in which: in a first step, a fructose syrup containing less than 15% glucose is subjected to an enzymatic isomerization using at least one enzyme capable of interconverting fructose and mannose, the enzymatic isomerization resulting in the production of a mixture of fructose and mannose containing at least 15% mannose, in a second step, the mixture of fructose and mannose is subjected to a chromatographic separation treatment so as to obtain at least two fractions one of which (fraction X1) is highly enriched with mannose and the other of which (fraction X2) is highly enriched with fructose, in a third step, fraction X2 is at least partially recycled to the top of the enzymatic isomerization step, in a fourth step, fraction X1, highly enriched with mannose, is hydrogenated so as to obtain a mannitol-rich syrup.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.