Compositions of iodophenyl sulfonates for X-ray visualization of the gastrointestinal tract

US5468466A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Edward R. Bacon · East Greenbush, US
• Sol J. Daum · Albany, US
• Kimberly G. Estep · Pottstown, US
• Kurt A. Josef · Wayne, US
• Brent Douty · Coatesville, US
• Carl R. Illig · Phoenixville, US

Key dates

• Filing date: Feb 1, 1994
• Grant date: Nov 21, 1995
• Expiry date: Feb 1, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C309/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene, lower-alkoxy-carbonyloxy; PA1 n=1-5; PA1 y=0-4; and PA1 w=1-4 in an aqueous pharmaceutically acceptable carrier.