Paclitaxel derivatives
US5468769A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 1993 |
| Grant date | Nov 21, 1995 |
| Priority date | — |
| Expiry date | Jul 15, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound or prodrug thereof having the formula ##STR1## wherein --OR.sup.1 comprises the C-13 side-chain of taxol and Z is selected from the group consisting of --CHO, --CH.sub.2 OH, --CH.sub.2 OR', --CH.sub.2 NR'R", --CH.dbd.NR', --CH.dbd.NOR', --CH.dbd.NNR.dbd.R", --CH(OH)SO.sub.3 Na, --CH.sub.2 OPO.sub.3.sup..dbd., --CH.sub.2 OSO.sub.3.sup..dbd., --CN and a radical of the formula ##STR2## where X and Y are independently selected from --O--, --S--, and --N(R')--, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.