Process for asymmetric total synthesis of camptothecin analogues
US5468859A · kind A · utility
20Cited by
1References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1994 |
| Grant date | Nov 21, 1995 |
| Priority date | — |
| Expiry date | Dec 23, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for the asymmetric synthesis of camptothecin analogs as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analog, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analog. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.