Transdominant negative proto-oncogene
US5470736A · kind A · utility
28Cited by
4References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 28, 1994 |
| Grant date | Nov 28, 1995 |
| Priority date | — |
| Expiry date | Mar 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/82
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides polynucleotide and polypeptide sequences for a trans-repressing protein of the Fos proto-oncogene family, where the polypeptide is characterized by having a leucine zipper domain and forming a heterodimer with a Jun related protein. This heterodimer is capable of biding to an AP-1 site and suppressing transcriptional transactivation of a promoter containing the AP-1 site.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.