Stably-transformed cells expressing human thiopurine methyltransferase

US5470737A · kind A · utility

Assignee

• Mayo Foundation for Medical Education and Research · US

Inventors

• Richard M. Weinshilboum · Rochester, US
• Ronald Honchel · Kasson, US
• Ibrahim A. Aksoy · Rochester, US
• Carol L. Szumlanski · Rochester, US
• Thomas Wood · Rochester, US
• Diane M. Otterness · Rochester, US
• Eric D. Wieben · Rochester, US

Key dates

• Filing date: Oct 3, 1994
• Grant date: Nov 28, 1995
• Expiry date: Oct 3, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/1007
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A recombinant DNA sequence is provided which encodes human thiopurine methyl transferase (TPMT), as well as a mammalian cell line having said recombinant DNA sequence incorporated into the genome thereof, so that the cells express high levels of human TPMT activity.