Tetrahydroprotoberberine quaternary ammonium compounds useful in for treating arrhythmia

US5470852A · kind A · utility

Assignees

• CHINA PHARMACEUTICAL UNIVERSITY · CN
• Administrative Center of New Drug Research, The State Pharmaceutical Administration of China · CN

Inventors

• Sixun Peng · Nanjing, CN
• Dezai Dai · Nanjing, CN
• Zhenya Huang · Nanjing, CN
• Wenlong Huang · Nanhu, CN
• Youqun Wang · Daguantang, CN
• Can Zhang · Beijing, CN
• Feng-Chao YU · Taipei, TW

Key dates

• Filing date: Oct 31, 1994
• Grant date: Nov 28, 1995
• Expiry date: Oct 31, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A tetrahydroprotoberberine quaternary ammonium compound represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R' and X are as defined in the specification. A method of preparing the compound is provided. The compounds can suppress arrhythmia and ventricular fibrillation, protect against myocardial ischemia, and can be conveniently orally administered.