Uncharged polynucleotide-binding polymers
US5470974A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 1994 |
| Grant date | Nov 28, 1995 |
| Priority date | — |
| Expiry date | Feb 25, 2014 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition of polymer molecules effective to bind, with substantially uniform binding affinity, to a single-stranded polynucleotide containing a target sequence of bases. The polymer molecules are composed of a sequence of base-pairing moieties effective to hydrogen bond to corresponding, complementary bases in the target sequence, under selected binding conditions, and a predominantly uncharged, achiral backbone supporting the base-pairing moieties at positions and in orientations which allow hydrogen bonding between the pairing moieties of the polymer and the corresponding complementary bases in the target sequence. The composition has diagnostic uses, in a solid-support assay system, and therapeutic uses involving inhibition or inactivation of target polynucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.