Pro-urokinase mutants
US5472692A · kind A · utility
20Cited by
1References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 2, 1993 |
| Grant date | Dec 5, 1995 |
| Priority date | — |
| Expiry date | Jul 2, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to thrombolytically active pro-urokinase (pro-UK) mutants comprising the amino acid sequence of native pro-UK, but including a mutation which causes the pro-UK mutants to induce less fibrinogenolysis and non-specific plasminogen activation than native pro-UK, to have at least a 10-fold lower intrinsic activity than native pro-UK, and to have substantially the same fibrin promotion and thrombolytic activity after plasmin activation compared to native pro-UK when administered to a patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.