Enzymatic process for cephalosporins
US5472853A · kind A · utility
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4Claims
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Key dates
| Filing date | Jun 18, 1993 |
| Grant date | Dec 5, 1995 |
| Priority date | — |
| Expiry date | Jun 18, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/911
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
N-Terminal .beta.,.gamma.-didehydrovaline di- and tri-peptides are reacted with isopenicillin N synthetase to form 3-exomethylenecepham-4-carboxylic acids, e.g., .delta.-(L-.alpha.-aminoadipoyl)-L-cysteinyl-D-.beta.,.gamma.-didehydroval ine is incubated with the purified enzyme to provide 7.beta.-(L-.alpha.-aminoadipoylamino)-3-exomethylenecepham-4-carboxylic acid. The 3-exocepham products are useful intermediates to 3-alkoxy-3-cephem and the 3-halo-3-cephem antibiotics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.