Patent · US Expired

Rhodotorula rubra useful in a process for the preparation of (.omega.-1)-hydroxyalkylxanthines

US5472873A · kind A · utility

0Cited by

1References

2Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Werner Aretz · Königstein, DE
Harald Furrer · Frankfurt am Main, DE
Ulrich Gebert · Königstein, DE
Heinz-Joachim Hinze · Wiesbaden, DE

Key dates

Filing date	Feb 10, 1994
Grant date	Dec 5, 1995
Priority date	—
Expiry date	Feb 10, 2014

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/911
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be converted into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereo-selectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.