Conductance measurements in organic solvents
US5472880A · kind A · utility
1Cited by
8References
16Claims
0Family size
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Key dates
| Filing date | Oct 3, 1994 |
| Grant date | Dec 5, 1995 |
| Priority date | — |
| Expiry date | Oct 3, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/06
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for quantitatively measuring an acid in a polar organic solvent involves adding a sterically hindered base, such as diisopropylentylamine, triethylamine or N-methylmorpholine to the solvent and measuring the conductance of the mixture. The method has particular relevance in monitoring the progress of preactivation, coupling and deprotection reactions in solid phase peptide synthesis (SPPS).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.