Synthesis of furanosyl compounds useful as intermediates in preparation of nucleoside analogues

US5473063A · kind A · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Bjorn Classon · Stockholm, SE
• Bengt Bertil Samuelsson · Skärholmen, SE
• Imgemar S. Kvarnstrom · Linköping, SE
• Lars Goran Svansson · Linköping, SE
• Stefan Carl Tore Svensson · Linköping, SE

Key dates

• Filing date: May 20, 1993
• Grant date: Dec 5, 1995
• Expiry date: May 20, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formulae ##STR1## wherein X is O; PA1 R.sup.1 is OH, phosphate, diphosphate, triphosphate or (CH.sub.2).sub.n --O--CH.sub.2 --O--P(.dbd.O)(OH).sub.2 wherein n is 0-2; PA1 R.sup.2 is H and R.sup.3 is CH.sub.3, CH.sub.2 OH, CH.sub.2 --O--CH.sub.3, CH.sub.2 SH, CH.sub.2 F or CH.sub.2 N.sub.3 ; or PA1 R3 is H and R.sup.2 is CH.sub.3, CH.sub.2 OH, CH.sub.2 --O--CH.sub.3, CH.sub.2 SH, CH.sub.2 F or CH.sub.2 N.sub.3 ; PA1 and Z is Cl, Br, I, acyloxy or alkoxy; are synthesized from acyclic intermediates and are subsequently useful in the preparation of nucleoside analogues with antiviral activity against retroviruses such as HIV and hepatitis B.