Process for preparing benzothiazepine derivatives
US5473066A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1994 |
| Grant date | Dec 5, 1995 |
| Priority date | — |
| Expiry date | Jan 19, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino) thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.