Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5475011A · kind A · utility
62Cited by
6References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1993 |
| Grant date | Dec 12, 1995 |
| Priority date | — |
| Expiry date | Mar 26, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and method for treatment of certain cancers with these new compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.