Thrombolytic peptide, production thereof, and thrombolytic agent
US5475089A · kind A · utility
4Cited by
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23Claims
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Key dates
| Filing date | Jun 14, 1993 |
| Grant date | Dec 12, 1995 |
| Priority date | — |
| Expiry date | Jun 14, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/31
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.