Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
US5475109A · kind A · utility
21Cited by
7References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 1994 |
| Grant date | Dec 12, 1995 |
| Priority date | — |
| Expiry date | Oct 17, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/96
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Dioxobutanoic acids substituted with piperidine or similar N-substituted saturated cycloalkyls are found to inhibit the cap-dependent endonuclease of influenza virus. These compounds are useful in the prevention or treatment of infection by influenza virus and the treatment of influenza, either as compound, pharmaceutically acceptable salts,. pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating influenza and methods of preventing or treating infection by influenza virus are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.