Anticalcification treatment for aldehyde-tanned biological tissue
US5476516A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1992 |
| Grant date | Dec 19, 1995 |
| Priority date | — |
| Expiry date | Mar 13, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/921
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having the formula: ##STR1## where R is CH.sub.2 OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C.sub.2 -C.sub.9 or a carboxyalkyl; or ##STR2## where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.