Methods for glycosylation inhibition using amino-benzoic acids and derivatives
US5476849A · kind A · utility
22Cited by
2References
33Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 3, 1993 |
| Grant date | Dec 19, 1995 |
| Priority date | — |
| Expiry date | Dec 3, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.