Amino-substituted benzenesulfonylureas and -thioureas and their use as pharmaceuticals

US5476850A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinrich Englert · Hofheim, DE
• Dieter Mania · Königstein, DE
• Jens Hartung · Rodgau, DE
• Heinz Gogelein · Frankfurt am Main, DE
• Joachim Kaiser · Frankfurt am Main, DE

Key dates

• Filing date: Dec 5, 1994
• Grant date: Dec 19, 1995
• Expiry date: Dec 5, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C335/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are described amino-substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## The compounds I are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death caused by arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for those cases in which arrhythmias are a result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.