Structural gene of pneumococcal protein
US5476929A · kind A · utility
32Cited by
3References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 3, 1993 |
| Grant date | Dec 19, 1995 |
| Priority date | — |
| Expiry date | Jun 3, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.
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