Enzymatic resolution of substituted 2-methyl-propionic acid

US5476965A · kind A · utility

Assignee

• GENENCOR INTERNATIONAL, INC. · US

Inventors

• Matthew W. Chase · East Berne, US
• Charles T. Goodhue · Rochester, US
• Robert Seemayer · Belmont, US
• Gregory M. Whited · Belmont, US

Key dates

• Filing date: Feb 18, 1994
• Grant date: Dec 19, 1995
• Expiry date: Feb 18, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/005
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided are enzymatic methods for the selective hydrolytic resolution of certain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a (.+-.) mixture of a .alpha.-substituted 2-methyl proprionic acid derivative. Specifically provided is the selective enzymatic resolution of either the R(+) or S(-) enantiomer of (.+-.)-ethyl ciprofibrate. Also provided are substantially pure enantiomers of R(+) and S(-) ciprofibrate.